Mamá Siempre Vuelve centers on the precarious dynamic between headstrong Olivia and her mercurial mother, Anna. Having inherited the TP53 gene mutation that caused her father's fatal bone cancer, Olivia is dead set on keeping her own symptoms a secret to fulfill his unrealized dream: riding the Pan-American Highway on his long-abandoned motorcycle. At the annual family gathering to celebrate his life, Olivia intends to reveal the meticulously restored bike, but instead finds herself relentlessly undermined by a mother who clearly doesn't want her following in her father's footsteps.