Victoria and Veronica Calderon are two Puerto Rican sisters living in New York City. They are as beautiful as they are tough, and they are both strippers. After getting fired from the strip club they were working at due to getting into a fight with another pair of strippers (brawls follow them wherever they go), Veronica receives a call from her ex-boyfriend Manny Alvarez (a Venezuelan drug trafficker) to come down to Venezuela, all expenses paid. Victoria doesn't trust Manny and is against the idea of her more naive sister going, but after failing to convince Veronica not to go, she reluctantly accompanies her to Venezuela. Little do they know that Manny (along with his accomplice Ozzie Ramirez) has only invited them so that he can use them as drug mule decoys when they attempt to fly back to New York City. The two sisters find this out the hard way when they are stopped by security at the airport in Caracas on their way back and their luggage is found to be carrying cocaine that Manny and Ozzie had secretly stashed in it.
Victoria and Veronica are then sentenced to fifteen years at Ana Maria Campos Prison in Maracaibo, Venezuela, a brutal women's penitentiary overseen by the sadistic and corrupt Captain Diana Mayorca, who rules with an iron fist. In addition to having to cope with her, the sisters also run afoul of the prison bullies, a crew of convicts led by Lidia Santana - who is in cahoots with Diana. In order to even the odds, the two sisters form an alliance with another crew of inmates led by the stoic Gigi Camacho, who is serving time for killing her cheating boyfriend with a car bomb. It all comes to a head during a brawl in the prison's shower area, with the two sisters and Gigi's crew emerging victorious.
Disappointed in Lidia, Captain Diana attempts to replace her by recruiting Victoria and Veronica - but the sisters reject her offer and end up battling the captain and her two deputies in Diana's office. During the melee Diana kills Veronica, and Victoria is then sent to solitary confinement; however she is later liberated with the help of Gigi during a wild prison riot. Amidst the chaos of the riot Victoria finds Diana, kills her, and escapes the prison. With Gigi's help she then crosses the border into Colombia and makes it back to New York City, where she is able to track down Manny and Ozzie, both of whom have also relocated to New York by this point. Victoria then finishes avenging her sister's death by killing Manny and Ozzie with a car bomb in much the way Gigi had killed her own boyfriend with one in Venezuela.
